| 04/30/2022 | Athletics | NH-Richmond | 6:30PM - 8:00PM | Richmond Little League / Diamond C | |
| 04/30/2022 | Rangers | Orioles | 6:30PM - 8:00PM | Algonac Little League / Field 4 Softball | |
| 05/01/2022 | Rangers | Orioles | 6:30PM - 8:00PM | Marine City Little League / Softball | |
| 05/03/2022 | Rangers | Athletics | 6:30PM - 8:00PM | IRA Little League / Softball #6 | |
| 05/03/2022 | Orioles | NH-Richmond | 6:30PM - 8:00PM | Richmond Little League / Diamond C | |
| 05/05/2022 | Rangers | NH-Richmond | 6:30PM - 8:00PM | Clark Street Fields / 5 Softball | |
| 05/05/2022 | Orioles | Athletics | 6:30PM - 8:00PM | IRA Little League / Softball #6 | |
| 05/10/2022 | Orioles | Rangers | 6:30PM - 8:00PM | Algonac Little League / Field 4 Softball | |
| 05/10/2022 | NH-Richmond | Brieden Ortho | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | |
| 05/12/2022 | Brieden Ortho | Orioles | 6:30PM - 8:00PM | Marine City Little League / Softball | |
| 05/12/2022 | Athletics | Rangers | 6:30PM - 8:00PM | Algonac Little League / Field 4 Softball | |
| 05/14/2022 | Athletics | Brieden Ortho | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | |
| 05/17/2022 | Athletics | NH-Richmond | 6:30PM - 8:00PM | IRA Little League / Softball #6 | |
| 05/17/2022 | Rangers | Brieden Ortho | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | |
| 05/19/2022 | Brieden Ortho | Orioles | 6:30PM - 8:00PM | Marine City Little League / Field #1 Girl's Player Pitch | |
| 05/19/2022 | NH-Richmond | Rangers | 6:30PM - 8:00PM | Algonac Little League / Field 4 Softball | |
| 05/24/2022 | Orioles | NH-Richmond | 6:30PM - 8:00PM | Marine City Little League / Field #1 Girl's Player Pitch | |
| 05/24/2022 | Athletics | Brieden Ortho | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | |
| 05/26/2022 | Orioles | Athletics | 6:30PM - 8:00PM | IRA Little League / Softball #6 | |
| 05/26/2022 | Brieden Ortho | Rangers | 6:30PM - 8:00PM | Algonac Little League / Field 4 Softball | |
| 05/31/2022 | Rangers | Athletics | 6:30PM - 8:00PM | IRA Little League / Softball #6 | |
| 05/31/2022 | NH-Richmond | Brieden Ortho | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | |
| 06/02/2022 | NH-Richmond | Athletics | 6:30PM - 8:00PM | IRA Little League / Softball #6 | |
| 06/02/2022 | Brieden Ortho | Orioles | 6:30PM - 8:00PM | Marine City Little League / Field #1 Girl's Player Pitch | |
| 06/04/2022 | Brieden Ortho | NH-Richmond | 3:00PM - 4:30PM | Richmond Little League / Diamond C | |
| 06/07/2022 | NH-Richmond | Rangers | 6:30PM - 8:00PM | Algonac Little League / Field 4 Softball | |
| 06/07/2022 | Athletics | Brieden Ortho | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | |
| 06/09/2022 | NH-Richmond | Orioles | 6:30PM - 8:00PM | Marine City Little League / Softball | |
| 06/09/2022 | Brieden Ortho | Rangers | 6:30PM - 8:00PM | Algonac Little League / Field 4 Softball | |
| 06/14/2022 | Athletics | Orioles | 6:30PM - 8:00PM | Marine City Little League / Field #1 Girl's Player Pitch | |
| 06/14/2022 | NH-Richmond | Brieden Ortho | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | |
| 06/15/2022 | TBD | Rangers | 12:00AM - 12:15AM | Algonac Little League / Field 4 Softball | Canceled |
| 06/15/2022 | Orioles | Athletics | 6:30PM - 8:00PM | Marine City Little League / Field #1 Girl's Player Pitch | Canceled |
| 06/15/2022 | Brieden Ortho | NH-Richmond | 6:30PM - 8:00PM | Marysville Little League / Field #5 Softball | Canceled |